THERAPEUTIC MILD HYPOTHERMIA TOWARDS BLOOD LACTATE LEVELS AND GLASGOW COMA SCORE IN SEVERE TRAUMATIC BRAIN INJURY

Indication for mild therapeutic hypothermia based on an initial Glasgow Coma Scale motor score

Although neurological evaluation using the Glasgow Coma Scale motor score is mandatory for post-cardiac arrest patients, further study is required to determine if this score can be used as an indicator for mild therapeutic hypothermia. Although the current study conducted by Natsukawa et al. presents interesting data, there are some critical issues regarding study design, selection bias, and in...

glasgow coma scale score in pediatric patients with traumatic brain injury; limitations and reliability

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Whole-brain apparent diffusion coefficient in traumatic brain injury: correlation with Glasgow Coma Scale score.

BACKGROUND AND PURPOSE Patients with traumatic brain injury (TBI) and low Glasgow coma scale (GCS) scores may have severe injury associated with cellular disruption that can be studied with whole-brain apparent diffusion coefficient (ADC) histograms. We retrospectively studied this hypothesis and correlated ADC with GCS. METHODS Twenty-one patients (37.81 +/- 41.3 years) with TBI were enrolle...

Glasgow Coma Scale Score in Pediatric Patients with Traumatic Brain Injury; Limitations and Reliability.

Revisiting therapeutic hypothermia for severe traumatic brain injury… again

Improved understanding of the molecular mechanisms of secondary brain injury has informed the optimum depth and duration of cooling and led to increased clinical interest in the therapeutic moderate hypothermia for severe traumatic brain injury over the past two decades. Although several large multi-center clinical trials have not found a treatment effect, multiple single-center trials have, an...